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Molecular Formula: C3H7Cl2MgLi
Appearance: Clear yellow to brown to gray solution
Molecular Weight: 145.24
Density: 1.05
Flash Point: -17 °C
Storage Conditions: Flammables area
Solubility: Soluble in ether solvents such as THF
Purity: 1.3 M solution in THF
Package Information: 100g, 500g, 1kg or customized
C3H7Cl2MgLi is one of the fastest and most efficient reagents for metal halide exchange (Mg–X exchange), capable of metallizing aryl and alkenyl halides under mild conditions (even −20 °C).
Compared to traditional Grignard reagents, it is more compatible with sensitive substrates such as esters, nitriles, and heterocyclic aromatic rings, exhibiting higher selectivity and facilitating the "late-stage functionalization" of complex molecules.
The addition of LiCl can improve solubility, making the system more stable and less prone to precipitation, thus providing better controllability for industrial scale-up.
Its controllable reaction rate and reproducibility make it a commonly used alkaline metallizing agent in pilot-scale and continuous flow microchannel processes.
C3H7Cl2MgLi is widely used in iodine-magnesium exchange reactions of aryl and alkenyl iodides. It is well-tolerant even to highly functionalized substrates, providing a convenient intermediate for subsequent cross-coupling and other reactions.
This compound can be used to synthesize specific isopropyl-substituted functional molecules or polymer precursors.
Due to their improved reaction properties, they are particularly used in the critical carbon-carbon bond formation steps in the construction of complex drug molecules.
In a flow process, rapid heat transfer and precise feeding can be achieved, forming highly selective intermediates under low-temperature conditions, making it suitable for the development of industrial "green process" routes.
It will decompose rapidly and generate heat when exposed to moisture, which may cause splashing or combustion. Therefore, it must be used in an inert atmosphere (N₂ or Ar) and must not come into contact with moisture or air.
Acids react immediately with C3H7Cl2MgLi, releasing heat, while oxidants trigger even more violent chemical reactions; therefore, they must be stored separately in cabinets.
If it comes into contact with skin, immediately rinse with plenty of water for at least 15 minutes and seek medical attention promptly; do not use organic solvents to wipe it off.
Metallization reactions are usually exothermic, and the dropping rate needs to be controlled at low temperatures (0 °C to −50 °C) to avoid cooling or boiling over.
1. What concentrations are available?
Commonly available are 1.0 M and 2.0 M THF solutions, but concentrations and solvents can also be customized according to customer requirements.
2. What are the key control points for industrial-scale use of C3H7Cl2MgLi?
These include reaction temperature, feed rate, moisture control, solvent purity, and thorough inertization of the equipment.
We are a professional Isopropylmagnesium Chloride Lithium Chloride Complex supplier. For more information or to purchase Isopropylmagnesium Chloride Lithium Chloride Complex(C3H7Cl2MgLi), please feel free to contact us via jomin@wolfabio.com.
Molecular Formula: C3H7Cl2MgLi
Appearance: Clear yellow to brown to gray solution
Molecular Weight: 145.24
Density: 1.05
Flash Point: -17 °C
Storage Conditions: Flammables area
Solubility: Soluble in ether solvents such as THF
Purity: 1.3 M solution in THF
Package Information: 100g, 500g, 1kg or customized
C3H7Cl2MgLi is one of the fastest and most efficient reagents for metal halide exchange (Mg–X exchange), capable of metallizing aryl and alkenyl halides under mild conditions (even −20 °C).
Compared to traditional Grignard reagents, it is more compatible with sensitive substrates such as esters, nitriles, and heterocyclic aromatic rings, exhibiting higher selectivity and facilitating the "late-stage functionalization" of complex molecules.
The addition of LiCl can improve solubility, making the system more stable and less prone to precipitation, thus providing better controllability for industrial scale-up.
Its controllable reaction rate and reproducibility make it a commonly used alkaline metallizing agent in pilot-scale and continuous flow microchannel processes.
C3H7Cl2MgLi is widely used in iodine-magnesium exchange reactions of aryl and alkenyl iodides. It is well-tolerant even to highly functionalized substrates, providing a convenient intermediate for subsequent cross-coupling and other reactions.
This compound can be used to synthesize specific isopropyl-substituted functional molecules or polymer precursors.
Due to their improved reaction properties, they are particularly used in the critical carbon-carbon bond formation steps in the construction of complex drug molecules.
In a flow process, rapid heat transfer and precise feeding can be achieved, forming highly selective intermediates under low-temperature conditions, making it suitable for the development of industrial "green process" routes.
It will decompose rapidly and generate heat when exposed to moisture, which may cause splashing or combustion. Therefore, it must be used in an inert atmosphere (N₂ or Ar) and must not come into contact with moisture or air.
Acids react immediately with C3H7Cl2MgLi, releasing heat, while oxidants trigger even more violent chemical reactions; therefore, they must be stored separately in cabinets.
If it comes into contact with skin, immediately rinse with plenty of water for at least 15 minutes and seek medical attention promptly; do not use organic solvents to wipe it off.
Metallization reactions are usually exothermic, and the dropping rate needs to be controlled at low temperatures (0 °C to −50 °C) to avoid cooling or boiling over.
1. What concentrations are available?
Commonly available are 1.0 M and 2.0 M THF solutions, but concentrations and solvents can also be customized according to customer requirements.
2. What are the key control points for industrial-scale use of C3H7Cl2MgLi?
These include reaction temperature, feed rate, moisture control, solvent purity, and thorough inertization of the equipment.
We are a professional Isopropylmagnesium Chloride Lithium Chloride Complex supplier. For more information or to purchase Isopropylmagnesium Chloride Lithium Chloride Complex(C3H7Cl2MgLi), please feel free to contact us via jomin@wolfabio.com.
