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Isopropylmagnesium Chloride

Chemical Formula: C3H7ClMg
CAS: 1068-55-9

Isopropylmagnesium Chloride (C3H7ClMg) is an important organometallic compound, belonging to the Grignard reagents. This compound typically exists in solution and is widely considered a highly efficient and commonly used alkylating agent in organic synthesis. Its outstanding high reactivity and wide application as a nucleophile make it an indispensable raw material in the synthesis of pharmaceuticals, polymer materials, and fine chemicals.
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Isopropylmagnesium Chloride Basic Properties

  • Molecular Formula: C3H7ClMg

  • Appearance: Yellow-brown to dark brown liquid

  • Molecular Weight: 102.85

  • Melting Point: 155-157 °C

  • Boiling Point: 256 °C

  • Density: 0.98 g/mL at 20 °C

  • Flash Point: 72 °F

  • Storage Conditions: Flammables + water-freezer (-20°C)e area

  • Solubility: React violently with water

  • Purity: 2.0 M in THF

  • Package Information: 100g, 500g, 1kg or customized

Isopropylmagnesium Chloride Key Features

High reactivity

As a typical Grignard reagent, isopropylmagnesium chloride exhibits good reactivity and can efficiently participate in organic reactions such as nucleophilic addition and nucleophilic substitution, thereby improving the overall efficiency of synthetic routes.

Stable performance

Under strictly anhydrous and oxygen-free conditions, it can be used as a substrate to extend chain segment structures, making it an important tool reagent for the design of many API intermediates.

Compatible with a variety of solution systems

Suitable solvents can be selected according to process requirements to improve reaction stability.

Isopropylmagnesium Chloride Main Applications

Fine chemicals

Isopropylmagnesium chloride can be used in polymer auxiliaries, surfactants, and other compounds containing branched alkyl segments.

Organic chemistry research

As a typical organometallic reagent, it can be used as a precursor for other complex organometallic structures, providing a basic building block for the development of catalytic systems.

Pharmaceutical intermediates

C3H7ClMg is an important raw material for the synthesis of pharmaceutical intermediates, often used to construct carbon chain skeletons, introduce branched structures, or carry out carbonylation synthesis.

Precautions

  1. Isopropylmagnesium chloride reacts violently with water and releases flammable gas, therefore it must be operated under anhydrous conditions, and equipment and reagents must be thoroughly dried.

  2. The solution is a highly flammable liquid and must be kept away from heat sources and open flames. Smoking is prohibited in the operating area, and appropriate fire extinguishing equipment (such as dry powder and dry sand) must be provided.

  3. This substance is highly corrosive to the respiratory tract, skin, and eyes. Therefore, it is essential to wear appropriate personal protective equipment and conduct the work in a well-ventilated area.

  4. It reacts rapidly with oxygen and other substances in the air, affecting the properties of the substance. Therefore, storage and transfer must be carried out under the protection of an inert gas (such as argon or nitrogen) to ensure that the container is sealed.

  5. In case of a leak, use an inert absorbent to treat it; do not flush directly with water to avoid a dangerous reaction.

FAQ

1. Are there any special conditions required for transportation?

No, it must be transported in UN-approved hazardous chemical containers under inert gas protection, and is generally classified as a flammable liquid.


2. What are the main uses of isopropylmagnesium chloride?

It is mainly used as a Grignard reagent in organic synthesis as an alkylating agent and nucleophile. It is widely used in the formation of carbon-carbon bonds and is an important raw material for the preparation of pharmaceutical intermediates, polymer monomers, and fine chemicals.


We are a professional Isopropylmagnesium Chloride supplier. For more information or to purchase Isopropylmagnesium Chloride(C3H7ClMg), please feel free to contact us via jomin@wolfabio.com.

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