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Benzylmagnesium Chloride

Chemical Formula: C7H7ClMg
CAS: 6921-34-2

Benzylmagnesium Chloride (C7H7ClMg) is a highly reactive and strongly nucleophilic Grignard reagent, typically existing in tetrahydrofuran (THF) or diethyl ether solutions, and widely used in pharmaceutical intermediates, fine chemicals, and synthetic materials. Due to the unique reactivity of its benzyl structure, it exhibits excellent efficiency and selectivity in a variety of electrophilic substrate reactions.
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Benzylmagnesium Chloride Basic Properties

  • Molecular Formula: C7H7ClMg

  • Appearance: Brown to purple liquid

  • Molecular Weight: 150.89

  • Boiling Point: 182 °C(Press: 16 Torr)

  • Density: 1.031 g/mL at 25 °C

  • Flash Point: 1 °F

  • Storage Conditions: Water-free area

  • Solubility: Soluble in ether solvents, such as THF and diethyl ether

  • Purity: 2.0 M in THF

  • Package Information: 100g, 500g, 1kg or customized

Benzylmagnesium Chloride Key Features

High reactivity

Benzylmagnesium chloride can rapidly undergo addition reactions with electrophilic groups such as aldehydes, ketones, and esters, making it a commonly used and highly efficient reagent for constructing complex organic structures.

Benzyl structure

The benzyl group has a stable electronic structure, which makes it more selective in the construction of carbon-carbon bonds and reduces the occurrence of side reactions.

Suitable for large-scale synthesis

In addition to laboratory research, C7H7ClMg is also commonly used in large-scale continuous synthesis in pharmaceutical and fine chemical plants, exhibiting good scalability.

Various customization options

We support different concentrations, different ether solvents, and different packaging specifications to meet the needs of different reaction systems.

Benzylmagnesium Chloride Main Applications

Pharmaceutical intermediates

They are commonly used in drug structure construction for aldehyde and ketone addition, heterocyclic construction, and the synthesis of structures containing aromatic side chains. They are one of the basic raw materials commonly used in pharmaceutical processes.

Fine chemicals

Used to construct benzyl derivatives, such as benzyl alcohol, benzyl substituted alkenes, and benzyl amines, they are important raw materials for high-value-added chemicals.

Organic synthesis

Benzylmagnesium chloride is used in academic research to explore novel addition reactions, structural extensions, and route development, and is a fundamental reagent in organic chemistry research.

Precautions

  1. Contact with moisture will cause it to decompose rapidly and generate heat, which may lead to splashing or even combustion. An inert atmosphere (nitrogen or argon) must be maintained throughout the process.

  2. It should be stored in a sealed container in a dry, cool place, away from light, heat sources and oxygen; use as soon as possible after opening and do not expose to the elements for extended periods.

  3. Avoid contact with reactive substances such as acids and oxidizing agents. Benzylmagnesium chloride reacts violently with acids and oxidizing agents, releasing a large amount of heat and gas.

  4. If skin contact occurs, rinse immediately with plenty of water; if discomfort occurs after inhaling vapors, move to a well-ventilated area and seek medical attention promptly.

  5. Protective equipment must be used throughout the operation, including protective gloves, goggles, protective clothing, and fume hood operation, to prevent injury from droplets, vapors, or reaction splashes.

FAQ

1. What are the differences between benzylmagnesium chloride and benzylmagnesium bromide?

Both have similar reaction types, but the benzylmagnesium chloride system is generally more stable, lower in cost, and suitable for large-scale synthesis.


2. Is benzylmagnesium chloride suitable for low-temperature reactions?

Yes, many addition reactions can be operated at 0 °C or lower to obtain higher selectivity.


3. What are some common problems in industrial applications?

Common challenges include excessively high solvent water content, incomplete equipment inertization, and exothermic reactions caused by excessively rapid feeding. Strict control of moisture, temperature, and feeding rate can significantly improve safety and yield.


We are a professional Benzylmagnesium Chloride supplier. For more information or to purchase Benzylmagnesium Chloride(C7H7ClMg), please feel free to contact us via jomin@wolfabio.com.

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