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Isopropenylmagnesium Bromide

Chemical Formula: C3H5BrMg
CAS: 13291-18-4

Isopropenylmagnesium Bromide (C3H5BrMg) is a typical Grignard reagent, usually existing in diethyl ether or THF solution. Due to its excellent nucleophilic addition ability and high reactivity with carbonyl compounds, it is widely used in pharmaceutical synthesis, fine chemicals, and various carbon-carbon bond construction reactions.
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Isopropenylmagnesium Bromide Basic Properties

  • Molecular Formula: C3H5BrMg

  • Appearance: White to yellow to orange crystalline powder

  • Molecular Weight: 145.28

  • Melting Point: 102-104 °C

  • Boiling Point: 67 °C

  • Density: 0.94 g/mL at 20 °C

  • Flash Point: −36 °F

  • Storage Conditions: 2-8°C

  • Solubility: Soluble in anhydrous diethyl ether, THF and other ether solvents

  • Purity: 0.5 M in THF

  • Package Information: 100g, 500g, 1kg or customized

Isopropenylmagnesium Bromide Key Features

High nucleophilic activity

isopropenylmagnesium bromide exhibits extremely high nucleophilicity, selectively adding to carbonyl groups to introduce isopropenyl groups, making it an efficient tool for constructing carbon-carbon bonds in complex organic molecules.

Adaptable to various solvent systems

C3H5BrMg exhibits stability in both diethyl ether and THF, allowing it to be flexibly adapted to different reaction temperatures and process requirements.

Suitable for cross-coupling reactions

This reagent can undergo cross-coupling reactions with various aryl halides in the presence of a palladium catalyst to obtain the corresponding styrene derivatives.

Good batch stability

Suitable for pharmaceutical R&D, API intermediate routes, and high-standard scientific research experiments, especially suitable for scenarios with high requirements for batch repeatability.

Isopropenylmagnesium Bromide Main Applications

Organic synthesis

Isopropenylmagnesium bromide is mainly used as a nucleophile and isopropenylating agent, undergoing addition reactions with carbonyl compounds. It is a key step in the preparation of complex organic molecules such as alcohols and ketones.

Polymer materials

It can be used to synthesize specific monomers or polymers, such as isotactic and stereoblock polymethyl methacrylate.

Materials and monomer modification

C3H5BrMg can be used to prepare functionalized monomers or to modify the chain ends of polymers, and is a commonly used active reagent in materials chemistry research.

Precautions

  1. Isopropenylmagnesium bromide reacts violently with water, even releasing flammable gases, posing a risk of combustion. Therefore, it must be handled under strictly anhydrous conditions.

  2. If the container contains water, the reagent will decompose immediately and its activity will decrease. Therefore, the container must be dried by baking or flame drying.

  3. It is recommended to store at 2–8°C and avoid strong light exposure to maintain solution stability and reactivity.

  4. It is highly reactive and may react violently with strong oxidants, therefore it must be stored separately.

  5. Excessive dripping speed may cause violent reactions or local temperature rises. A dripping funnel should be used in the fume hood to control the feeding rate.

FAQ

1. Can it be used in conjunction with other Grignard reagents?

Yes, but it is necessary to confirm that no side reactions will occur between the two, and to ensure that the entire system is kept anhydrous and oxygen-free.


2. Do you provide COA/TDS/SDS?

Usually, complete quality documentation is available, including COA, TDS, SDS, and batch purity and solvent analysis data.


We are a professional Isopropenylmagnesium Bromide supplier. For more information or to purchase Isopropenylmagnesium Bromide(C3H5BrMg), please feel free to contact us via jomin@wolfabio.com.

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