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(R)-(-)-Phenylsuccinic Acid丨CAS 46292-93-7

CAS: 46292-93-7
Chemical Formula/Abbreviation: C10H10O4

(R)-(-)-Phenylsuccinic Acid (CAS No. 46292-93-7) is an organic dicarboxylic acid with a well-defined chiral structure, typically appearing as a white to off-white crystalline solid. Owing to its chemical stability and clearly defined enantiomeric configuration, this compound is widely used as a chiral intermediate and plays an important role in pharmaceutical synthesis, fine chemical research and development, as well as asymmetric synthesis systems.
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(R)-(-)-Phenylsuccinic Acid Basic Properties

Synonyms(R)-(-)-PHENYLSUCCINIC ACID;(R)-(-)-PHENYLSUCCINIC ACID 99+%;(R)-2-Phenylbutanedioic acid;(2R)-2-Phenylbutanedioic acid;(R)2-Phenylsuccinicacid
Molecular FormulaC10H10O4
AppearanceWhite to off-white solid
Specific Rotation

-175 º (c=1%, acetone)

Optical Rotation[α]20/D 175±4°, c = 1% in acetone
Molecular Weight194.18
Melting Point173-176 °C
Boiling Point

290.62°C (rough estimate)

Density1.2534 (rough estimate)
Refractive Index1.5430 (estimate)
Acidity Coefficient (pKa)3.60±0.10(Predicted)
Storage ConditionsSealed in a dry, room-temperature environment
Solubility

Soluble in acetone (a small amount) and methanol (a small amount)

Purity≧ 98%
Package Information100g, 500g, 1kg, or customized

(R)-(-)-Phenylsuccinic Acid Key Features

Well-defined (R) chiral configuration

(R)-(-)-Phenylsuccinic Acid possesses a stable and clearly defined enantiomeric configuration, making it a highly reliable chiral source for synthetic routes that require strict control of stereoselectivity.

Good chemical stability and ease of handling

This compound remains stable under typical laboratory and industrial operating conditions, is not prone to spontaneous decomposition, and is therefore convenient for weighing, storage, and scale-up applications.

Mature synthetic routes and controllable quality

As a commonly used chiral dicarboxylic acid, its synthesis and purification processes are relatively well established, enabling consistent batch-to-batch quality in research and custom synthesis applications.

Compatibility with multiple functional group transformations

The molecular structure contains two carboxyl groups, which readily undergo derivatization reactions such as esterification and amidation, thereby expanding its applicability in complex organic synthesis.

(R)-(-)-Phenylsuccinic Acid Main Applications

Pharmaceutical intermediates and chiral synthesis

(R)-(-)-Phenylsuccinic Acid is commonly used in the preparation of chiral drug molecules or pharmaceutical intermediates, particularly in synthetic systems that require stringent control of enantiomeric purity.

Fine chemicals and functional materials research and development

Its stable molecular framework and ease of structural modification give it potential value in the early-stage development of functional organic molecules and specialty chemicals.

Asymmetric synthesis research

In studies of asymmetric catalysis and chiral resolution, this compound can serve as a substrate or a reference chiral compound for evaluating reaction stereoselectivity and efficiency.

Academic research and methodological development

In universities and research institutions, (R)-(-)-Phenylsuccinic Acid is frequently used in the development of new synthetic routes, optimization of reaction conditions, and studies of structure–property relationships.

Precautions

  1. It is recommended to store the product in a tightly sealed container in a cool, dry, and well-ventilated environment, and to avoid prolonged exposure to humid air.

  2. As the molecule contains organic carboxylic acid groups, it should be kept away from strong oxidizing agents to prevent unwanted side reactions.

  3. During handling, appropriate personal protective equipment, such as protective gloves and safety goggles, is recommended to prevent direct contact of dust or solutions with the skin and eyes.

  4. In the event of skin contact, rinse immediately with plenty of water. If irritation or discomfort persists, seek medical attention promptly.

  5. Laboratory waste should be disposed of in accordance with local regulations governing organic acid chemicals and must not be discharged arbitrarily.

  6. Transportation precautions: During transport, exposure to high temperatures and severe vibration should be avoided. Packaging integrity must be ensured to prevent moisture absorption or contamination.

FAQ

1. What is (R)-(-)-Phenylsuccinic Acid?

(R)-(-)-Phenylsuccinic Acid is a chiral dicarboxylic acid with an (R) configuration. It has a CAS number of 46292-93-7 and a molecular formula of C10H10O4, with a molecular weight of 194.18. It has a reported melting point of 173–176 °C and is commonly used as a chiral intermediate in pharmaceutical and fine chemical synthesis. 


2. What are the main application areas of (R)-(-)-Phenylsuccinic Acid?

It is mainly used in the synthesis of pharmaceutical intermediates, asymmetric synthesis research, fine chemical development, and methodological studies in academic and research laboratories. 


3. Is this product suitable for industrial-scale use?

Provided that mature production processes and quality control systems are in place, (R)-(-)-Phenylsuccinic Acid can be used for pilot-scale or industrial-scale production, subject to evaluation based on the target product and process requirements. 


Wolfa professionally supplies (R)-(-)-Phenylsuccinic Acid, supporting small-batch sampling and large-volume procurement needs. Packaging options include ordinary glass bottles, glass ampoules, metal ampoules, etc.


For product analysis reports (such as COA) or procurement consulting, please feel free to contact us at jomin@wolfabio.com at any time.

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