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Molecular Formula: C4H9Li
Appearance: Yellow liquid
Molecular Weight: 64.06
Melting Point: -95 °C
Boiling Point: 80 °C
Density: 0.68 g/mL at 20 °C
Vapor Pressure: 163 hPa ( 20 °C)
Flash Point: 10 °F
Storage Conditions: 2-8°C
Solubility: Miscible with diethyl ether and cyclohexane
Package Information: 100g, 500g, 1kg, or customized
Under strictly controlled conditions, N-Butyllithium can achieve highly selective reactions, such as preferential deprotonation reactions rather than addition to intramolecular electrophilic centers.
This compound is an extremely strong base and nucleophile with an extremely high pKa, enabling it to perform a variety of deprotonation reactions that cannot be accomplished by conventional bases. It has irreplaceable value in the construction of complex organic structures.
N-Butyllithium can also undergo lithium-halogen exchange reactions and lithium-metal transfer metallization reactions (such as organotin).
It offers flexible supply options, allowing for the selection of systems such as hexane, pentane, and cyclohexane to suit the application, making it more suitable for large-scale plant operations and precise laboratory control needs.
N-Butyllithium can be used for the deprotonation of a variety of substrates, and is particularly suitable for generating high-energy intermediates such as enol lithium, aryl lithium, and alkynyl lithium, which is a key reaction step in the construction of drug molecules.
It is also used to prepare various organometallic compounds, as well as to synthesize oligomers and dendritic macromolecules with specific structures for research and application.
C4H9Li is widely used in a variety of products, including pharmaceutical intermediates, fragrances, and electronic chemical precursors, due to its high selectivity, which can effectively reduce the generation of by-products and improve product purity.
It must be stored in a cool, dry, well-ventilated area away from fire and heat sources. The packaging must be absolutely sealed and stored at a low temperature of 2-8℃.
All operations involving N-Butyllithium must be performed under the protection of an inert gas (nitrogen or argon), and the operating environment must be absolutely anhydrous.
Due to its extremely high activity, it must be handled using a completely dry metal syringe or the Schlenk system.
Open flames are strictly prohibited in the workplace. Dry sand or Class D dry powder fire extinguishers should be readily available within easy reach. Never use water, foam, or chloroalkane fire extinguishers to extinguish N-Butyllithium fires.
Do not operate under normal ventilation conditions. Experiments or dispensing operations should be carried out in a dedicated fume hood, drying box, or glove box to ensure safety.
Waste liquid cannot be discharged directly and must be treated in accordance with hazardous chemical standards. It must be treated by professionals using a slow quenching method to avoid accidents caused by uncontrolled reactions.
1. What is N-Butyllithium? How does it differ from other organolithium compounds?
N-Butyllithium, with the chemical formula C4H9Li, is one of the most commonly used and important organolithium reagents, exhibiting strong base and strong nucleophilicity. Compared to sec-BuLi or t-BuLi, its reactivity is slightly weaker but more controllable, making it suitable for a wider range of industrial and laboratory applications. It is typically used in alkane solution form, and due to its extreme sensitivity to air and water, it requires careful handling.
2. How to properly handle N-Butyllithium in the laboratory?
A dry glass syringe must be used under positive pressure with an inert gas atmosphere. First, flush the syringe with inert gas to displace the air, then draw the required amount from the reagent bottle under the protective atmosphere. During drawing and transfer, the needle tip should always be kept under an inert atmosphere or below the liquid surface to prevent spontaneous combustion upon contact with air. After use, the syringe should be immediately cleaned with a dry, inert solvent.
3. What are the common concentrations of C4H9Li solutions?
We typically supply concentrations of 1.6M, 2.0M, 2.5M, and 2.6M (hexane or pentane systems), and can customize solutions according to user process requirements.
4. Can it be operated in an open container for a short period of time?
No, even contact with a small amount of air will cause rapid oxidation or even spontaneous combustion. Operation must be carried out under the protection of an inert gas.
We are a professional N-Butyllithium supplier. For more information or to purchase N-Butyllithium(C4H9Li), please feel free to contact us via jomin@wolfabio.com.
Molecular Formula: C4H9Li
Appearance: Yellow liquid
Molecular Weight: 64.06
Melting Point: -95 °C
Boiling Point: 80 °C
Density: 0.68 g/mL at 20 °C
Vapor Pressure: 163 hPa ( 20 °C)
Flash Point: 10 °F
Storage Conditions: 2-8°C
Solubility: Miscible with diethyl ether and cyclohexane
Package Information: 100g, 500g, 1kg, or customized
Under strictly controlled conditions, N-Butyllithium can achieve highly selective reactions, such as preferential deprotonation reactions rather than addition to intramolecular electrophilic centers.
This compound is an extremely strong base and nucleophile with an extremely high pKa, enabling it to perform a variety of deprotonation reactions that cannot be accomplished by conventional bases. It has irreplaceable value in the construction of complex organic structures.
N-Butyllithium can also undergo lithium-halogen exchange reactions and lithium-metal transfer metallization reactions (such as organotin).
It offers flexible supply options, allowing for the selection of systems such as hexane, pentane, and cyclohexane to suit the application, making it more suitable for large-scale plant operations and precise laboratory control needs.
N-Butyllithium can be used for the deprotonation of a variety of substrates, and is particularly suitable for generating high-energy intermediates such as enol lithium, aryl lithium, and alkynyl lithium, which is a key reaction step in the construction of drug molecules.
It is also used to prepare various organometallic compounds, as well as to synthesize oligomers and dendritic macromolecules with specific structures for research and application.
C4H9Li is widely used in a variety of products, including pharmaceutical intermediates, fragrances, and electronic chemical precursors, due to its high selectivity, which can effectively reduce the generation of by-products and improve product purity.
It must be stored in a cool, dry, well-ventilated area away from fire and heat sources. The packaging must be absolutely sealed and stored at a low temperature of 2-8℃.
All operations involving N-Butyllithium must be performed under the protection of an inert gas (nitrogen or argon), and the operating environment must be absolutely anhydrous.
Due to its extremely high activity, it must be handled using a completely dry metal syringe or the Schlenk system.
Open flames are strictly prohibited in the workplace. Dry sand or Class D dry powder fire extinguishers should be readily available within easy reach. Never use water, foam, or chloroalkane fire extinguishers to extinguish N-Butyllithium fires.
Do not operate under normal ventilation conditions. Experiments or dispensing operations should be carried out in a dedicated fume hood, drying box, or glove box to ensure safety.
Waste liquid cannot be discharged directly and must be treated in accordance with hazardous chemical standards. It must be treated by professionals using a slow quenching method to avoid accidents caused by uncontrolled reactions.
1. What is N-Butyllithium? How does it differ from other organolithium compounds?
N-Butyllithium, with the chemical formula C4H9Li, is one of the most commonly used and important organolithium reagents, exhibiting strong base and strong nucleophilicity. Compared to sec-BuLi or t-BuLi, its reactivity is slightly weaker but more controllable, making it suitable for a wider range of industrial and laboratory applications. It is typically used in alkane solution form, and due to its extreme sensitivity to air and water, it requires careful handling.
2. How to properly handle N-Butyllithium in the laboratory?
A dry glass syringe must be used under positive pressure with an inert gas atmosphere. First, flush the syringe with inert gas to displace the air, then draw the required amount from the reagent bottle under the protective atmosphere. During drawing and transfer, the needle tip should always be kept under an inert atmosphere or below the liquid surface to prevent spontaneous combustion upon contact with air. After use, the syringe should be immediately cleaned with a dry, inert solvent.
3. What are the common concentrations of C4H9Li solutions?
We typically supply concentrations of 1.6M, 2.0M, 2.5M, and 2.6M (hexane or pentane systems), and can customize solutions according to user process requirements.
4. Can it be operated in an open container for a short period of time?
No, even contact with a small amount of air will cause rapid oxidation or even spontaneous combustion. Operation must be carried out under the protection of an inert gas.
We are a professional N-Butyllithium supplier. For more information or to purchase N-Butyllithium(C4H9Li), please feel free to contact us via jomin@wolfabio.com.
