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Pentafluoroethanesulfonamide

Chemical Formula: C2H2F5NO2S
CAS: 78491-70-0

Pentafluoroethanesulfonamide is a stable fluorosulfonamide compound, typically existing as a white to off-white solid. Due to its strong polarity and good heat resistance, pentafluoroethanesulfonamide is widely used as an intermediate in fluorinated chemicals and plays an important role in the preparation of specialty materials and fine chemicals. The strong C–F bonds in its molecular structure make it an essential raw material in many fluorination processes.
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Pentafluoroethanesulfonamide Basic Properties

  • Molecular Formula: C2H2F5NO2S

  • Appearance: White to almost white powder crystals

  • Molecular Weight: 199.1

  • Melting Point: 80 °C

  • Solubility: Soluble in water

  • Purity: 98%

  • Package Information: 100g, 500g, 1kg, or customized

Pentafluoroethanesulfonamide Key Features

High stability

Pentafluoroethanesulfonamide possesses a highly polar –SO₂NH– structure and a highly stable C–F bond, which allows it to remain chemically inert even at high temperatures, making it ideal as an intermediate and key structural unit for fluorine-containing materials.

Excellent reaction selectivity

Due to the excellent reaction control of the sulfonamide structure, C2H2F5NO2S is often used in organic synthesis to direct reactions of specific functional groups, improve the yield and purity of target molecules, and help optimize process routes.

Excellent solubility

Its excellent solubility in common organic solvents makes it ideal for continuous reactions, secondary synthesis, and downstream derivative preparation, adaptable to various working conditions in both laboratory and factory production.

Pentafluoroethanesulfonamide Main Applications

Pharmaceutical intermediates

The –SO₂NH– functional group can serve as a key linking unit, and is used to develop more complex and biologically active pharmaceutical compounds, playing an important role in drug discovery and screening.

Materials synthesis

This compound can serve as a precursor for the synthesis of more complex fluorinated chemicals, such as its derived bis(pentafluoroethanesulfonyl)imine structures, and is of significant value in the preparation of advanced electrolyte salts, catalysts, and functional polymers.

Specialty materials

Due to its strong polarity and heat resistance, pentafluoroethanesulfonamide can be used as a high-performance surfactant, polymer additive, or precursor of fluorinated monomers to improve the heat resistance, hydrophobicity, and chemical stability of materials.

Precautions

  1. When storing pentafluoroethanesulfonamide, avoid moisture absorption, keep the container tightly sealed, and store in a dry environment.

  2. Although the product has good heat resistance, it may decompose at high temperatures, producing irritating gases. It should be kept away from direct sunlight or storage environments with temperatures exceeding 40°C.

  3. Sulfonamide structures are sensitive to strong bases, which can accelerate their hydrolysis or decomposition. Therefore, they should be kept away from strong alkaline reagents such as sodium hydroxide and potassium hydroxide.

  4. If the substance accidentally comes into contact with skin or eyes, immediately rinse with plenty of water for 15 minutes and seek medical attention if necessary. Prolonged contact may cause mild irritation.

  5. It is recommended to wear protective gloves, goggles, and lab coats to avoid inhaling dust. Fine dust may be generated when pouring the solid material; therefore, operations should be performed inside a fume hood whenever possible.

  6. The dissolution process may be slightly exothermic. In industrial settings, the dissolution rate should be controlled to avoid localized temperature increases that could affect reaction stability.

FAQ

1. What is Pentafluoroethanesulfonamide?

Pentafluoroethanesulfonamide is a sulfonamide chemical containing a pentafluoro structure, with the chemical formula C2H2F5NO2S and a molecular weight of 199.1. It is mainly used in the synthesis of fluorine-containing compounds and the production of specialty materials.


2. What are the main uses of pentafluoroethanesulfonamide?

This product is mainly used in the synthesis of pharmaceutical intermediates, agrochemical intermediates, fluorinated surfactants, and advanced fluorinated materials.


3. Can it be used for large-scale production?

Yes, due to its good solubility, structural stability, and high reaction selectivity, it is very common in laboratory, pilot-scale, and factory-scale production.


We are a professional Pentafluoroethanesulfonamide supplier. For more information or to purchase Pentafluoroethanesulfonamide(C2H2F5NO2S), please feel free to contact us via jomin@wolfabio.com.

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