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Molecular Formula: C38H54ClN3O10S
Appearance: White to light yellow solid
Molecular Weight: 780.37
Melting Point: 185-187 °C (decomp)
Boiling Point: 943.2±65.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
Storage Conditions: -20°C
Solubility: DMSO : 100 mg/mL (128.14 mM)
Package Information: 500g, 5kg or customized
As a structural analogue of maytansine, Dm4 can be conjugated with receptor-targeting antibodies for precise delivery and exhibits highly efficient microtubule inhibitory activity against tumor cells. This is the core reason why it is widely used in ADC technology.
As a cytotoxic maytansine alkaloid, it can cause mitotic arrest and subsequent apoptotic cell death.
C38H54ClN3O10S has a clear melting point and high purity, which is helpful for its quality control and application in research and development and production.
It can be used not only for traditional antibody conjugation, but also for delivery systems of biomolecules, peptides and nanocarriers, making it suitable for a wide range of applications.
Dm4 is a key toxin module in many ADC prototype drugs. It is typically conjugated to immunoglobulin antibodies at specific sites to develop highly selective and efficient anticancer drugs that kill tumor cells.
This compound, as a microtubule inhibitor, can be used to study related mechanisms such as cell cycle regulation and microtubule system dynamics.
Dm4 is commonly used as a base toxin to evaluate the conjugation efficiency, stability, and pharmacokinetic properties of different linkers.
Dm4 must be stored in an environment below -20°C in a dry, sealed container.
As a potent cytotoxic drug, it is extremely toxic to organisms and must be handled with extreme care, requiring the wearing of gloves and goggles, and carried out in a fume hood.
Avoid contact with incompatible substances. Due to its high cytotoxicity, all operations should follow strict safety procedures, and the supplier's Material Safety Data Sheet (MSDS) should be consulted for detailed emergency response guidelines.
Frequent freeze-thaw cycles are not recommended as they may cause structural damage. It is recommended to aliquot the experimental dose and store the product accordingly.
1. What is the mechanism of action of Dm4?
It mainly works by binding to tubulin, inhibiting tubulin polymerization and microtubule assembly, disrupting microtubule dynamics, leading to arrested cell mitosis, and ultimately inducing apoptosis.
2. Can Dm4 be stored long-term?
Yes, but it must be stored sealed in a dry, light-protected environment at -20°C, and frequent opening or exposure to air should be avoided.
3. How should it be dissolved?
DMSO, DMF, or methanol are recommended as solvents. If used for coupling reactions, ensure the solvent is dry and the operation is carried out under anhydrous conditions.
We are a professional Dm4 supplier. For more information or to purchase Dm4(C38H54ClN3O10S), please feel free to contact us via jomin@wolfabio.com.
Molecular Formula: C38H54ClN3O10S
Appearance: White to light yellow solid
Molecular Weight: 780.37
Melting Point: 185-187 °C (decomp)
Boiling Point: 943.2±65.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
Storage Conditions: -20°C
Solubility: DMSO : 100 mg/mL (128.14 mM)
Package Information: 500g, 5kg or customized
As a structural analogue of maytansine, Dm4 can be conjugated with receptor-targeting antibodies for precise delivery and exhibits highly efficient microtubule inhibitory activity against tumor cells. This is the core reason why it is widely used in ADC technology.
As a cytotoxic maytansine alkaloid, it can cause mitotic arrest and subsequent apoptotic cell death.
C38H54ClN3O10S has a clear melting point and high purity, which is helpful for its quality control and application in research and development and production.
It can be used not only for traditional antibody conjugation, but also for delivery systems of biomolecules, peptides and nanocarriers, making it suitable for a wide range of applications.
Dm4 is a key toxin module in many ADC prototype drugs. It is typically conjugated to immunoglobulin antibodies at specific sites to develop highly selective and efficient anticancer drugs that kill tumor cells.
This compound, as a microtubule inhibitor, can be used to study related mechanisms such as cell cycle regulation and microtubule system dynamics.
Dm4 is commonly used as a base toxin to evaluate the conjugation efficiency, stability, and pharmacokinetic properties of different linkers.
Dm4 must be stored in an environment below -20°C in a dry, sealed container.
As a potent cytotoxic drug, it is extremely toxic to organisms and must be handled with extreme care, requiring the wearing of gloves and goggles, and carried out in a fume hood.
Avoid contact with incompatible substances. Due to its high cytotoxicity, all operations should follow strict safety procedures, and the supplier's Material Safety Data Sheet (MSDS) should be consulted for detailed emergency response guidelines.
Frequent freeze-thaw cycles are not recommended as they may cause structural damage. It is recommended to aliquot the experimental dose and store the product accordingly.
1. What is the mechanism of action of Dm4?
It mainly works by binding to tubulin, inhibiting tubulin polymerization and microtubule assembly, disrupting microtubule dynamics, leading to arrested cell mitosis, and ultimately inducing apoptosis.
2. Can Dm4 be stored long-term?
Yes, but it must be stored sealed in a dry, light-protected environment at -20°C, and frequent opening or exposure to air should be avoided.
3. How should it be dissolved?
DMSO, DMF, or methanol are recommended as solvents. If used for coupling reactions, ensure the solvent is dry and the operation is carried out under anhydrous conditions.
We are a professional Dm4 supplier. For more information or to purchase Dm4(C38H54ClN3O10S), please feel free to contact us via jomin@wolfabio.com.
