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Oxalyl Chloride丨CAS 79-37-8

CAS: 79-37-8
Chemical Formula: C2Cl2O2

Oxalyl Chloride (C2Cl2O2) is a white metallic crystal. Due to its high reactivity and strong acyl chlorination ability, it is considered an irreplaceable core raw material in the fields of fine chemical and pharmaceutical intermediate synthesis. As an important acyl chlorination reagent with the chemical formula C2Cl2O2, it exhibits extremely high selectivity and reaction efficiency in many fine chemical reactions.
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Oxalyl Chloride Basic Properties

Molecular FormulaC2Cl2O2
AppearanceWhite metallic crystals
Molecular Weight239.26
Melting Point1114°C
Boiling Point1281°C (estimate)
Density7.5 g/mL at 25 °C(lit.)
Refractive Index3.921
Flash Point4.00°C
Storage Conditions2-8°C
SolubilitySoluble in acids, insoluble in water and alkalis
Purity≧98%
Package Information500g, 5kg, or customized
LogisticsExperienced in handling Class 8 (Corrosive) and 6.1 (Toxic) shipments to ensure safe arrival

Oxalyl Chloride Key Features

Extremely high reaction efficiency

Oxalyl chloride is a commonly used acyl chloride agent in organic chemistry, particularly suitable for converting carboxylic acids into acyl chlorides. High-yield conversion can be achieved under mild conditions, minimizing side reactions.

Suitable for the synthesis of fine chemicals

Its decomposition products are CO and CO2, which do not introduce additional complex byproducts, making it more suitable for the preparation of pharmaceutical or electronic grade materials with high structural purity requirements.

Controllable reaction

The reaction temperature is controllable, and it exhibits mild reactivity to many sensitive substrates, improving the overall controllability of the synthesis.

Wide applicability

Oxalyl chloride is compatible with a variety of solvents, does not require particularly demanding reaction equipment, and is suitable for chemical production lines of various scales.

Oxalyl Chloride Main Applications

Pharmaceutical intermediates

Oxalyl chloride is commonly used to activate carboxylic acids to acyl chlorides, which are then used in the synthesis of esters, amides, and heterocyclic compounds. It is frequently used in the preparation of many anti-disease drugs, organocatalysts, and hydrazide intermediates.

Fine chemicals and specialty materials

Used in the synthesis of aromatic acyl chlorides, organic dye precursors, structural modifiers for polymer materials, and in thiolation, amidation, and specific condensation reactions.

Electrochemistry

C2Cl2O2 is used in the synthesis of some electronic-grade monomers and ligands for applications requiring low metal residue.

Agricultural chemical technical materials

Commonly used for structural modification of agricultural chemical technical materials, such as amidation, esterification, and construction of active units.

Swern Oxidation

Essential activator for the oxidation of alcohols to aldehydes/ketones.

Precautions

  1. Oxalyl chloride decomposes violently in water, releasing HCl and CO. Therefore, it must be stored in a strictly dry place, and the container must be sealed, moisture-proof, and protected from humid air.

  2. Strong alkalis, alcohols, amines and other reactive substances can react rapidly with oxalyl chloride, which may cause exothermic reactions or even dangerous situations. Therefore, they must not be coexisted or mixed.

  3. Store in a cool, dry, explosion-proof, and well-ventilated warehouse, away from fire and heat sources. It is recommended to store it in a dedicated corrosion-resistant container.

  4. Because it releases irritating acid mist and volatile gases, laboratory personnel must wear acid-resistant gloves, protective goggles, and protective clothing.

  5. If the substance accidentally comes into contact with skin, immediately rinse with plenty of water for at least 15 minutes. If burns or irritation occur, seek immediate medical attention. Never use alkalis to neutralize the substance, as this may worsen the injury.

FAQ

1. Does oxalyl chloride always need to be used under anhydrous conditions?

Yes, because it decomposes immediately upon contact with water, becoming ineffective and producing corrosive gases such as HCl. Therefore, the reactive system must be kept completely dry.


2. Can oxalyl chloride be used with substrates other than carboxylic acids?

Yes, it is also suitable for amidation, condensation, and oxidation reactions, but the reaction conditions need to be determined based on the substrate structure.


3. How soluble is oxalyl chloride?

It is soluble in acids, but insoluble in water and alkalis.


We are a professional Oxalyl Chloride supplier. For more information or to purchase Oxalyl Chloride(C2Cl2O2), please feel free to contact us via jomin@wolfabio.com.

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